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Adult bone formation

Although bone initially forms during fetal development, it undergoes secondary ossification after birth and is remodeled throughout life. When a tooth is lost and not replaced, bone remodeling will fill in much of the socket. Although the remodeling will be obvious within a few weeks especially when smiling , the process will continue for some months. Bones are rigid organs that constitute part of the endoskeleton of vertebrates.
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Positive Regulation of Adult Bone Formation by Osteoblast-Specific Transcription Factor Osterix

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Bone Formation and Development | Anatomy & Physiology

Osterix Osx is essential for osteoblast differentiation and bone formation, because mice lacking Osx die within 1 h of birth with a complete absence of intramembranous and endochondral bone formation. Perinatal lethality caused by the disruption of the Osx gene prevents studies of the role of Osx in bones that are growing or already formed. Osx was inactivated in all osteoblasts by Col1a1-Cre with the activity of Cre recombinase under the control of the 2. Even though no bone defects were observed in newborn mice, Osx inactivation with 2. BMD and bone-forming rate were decreased in lumbar vertebra, and the cortical bone of the long bones was thinner and more porous with reduced bone length.
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Normal Bone Anatomy and Physiology

The adult process of new bone formation by calcification front is where the new bone formation meets the osteoid seam. Calcification front is the dividing line where the osteoid seam meets older mineralized bone. The process of ontogenesis is the formation on a new bone tissue. This is a process where new bone material is laid down using cells known as osteoblasts.
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By the sixth or seventh week of embryonic life, the actual process of bone development, ossification osteogenesis , begins. There are two osteogenic pathways—intramembranous ossification and endochondral ossification—but in the end, mature bone is the same regardless of the pathway that produces it. During intramembranous ossification , compact and spongy bone develops directly from sheets of mesenchymal undifferentiated connective tissue.
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